光固化3D打印制备PLA/β-TCP生物支架及性能
王波群1，揭晓华2，雷芳1，李奖1
1.东莞职业技术学院智能制造学院，广东东莞 523808； 2.广东工业大学材料与能源学院，广州 510006
Preparation and Properties of PLA/β-TCP Bio-scaffolds Based on Photocurable 3D Printing
Wang Boqun1, Jie Xiaohua2, Lei Fang1, Li Jiang1
1.School of Advanced Manufacturing Technology,Dongguan Polytechnic College,Dongguan 523808,China; 2.School of Materials and Energy,Guangdong University of Technology,Guangzhou 510006,China
摘要：为制备表面具有沟槽纹路结构 、粗糙度可调控、压缩强度高的骨组织工程支架，解决传统的活塞挤出式 3D打印难以获得具有可控纹路的纤维表面特征的问题 ，以光固化生物基聚乳酸(PLA)，β-磷酸三钙 (β-TCP)为原料 ，γ-(2，3-环氧丙氧基) 丙基三甲氧基硅烷偶联剂为改性剂，采用球磨搅拌法制备 β -TCP 含量不同的 PLA/β -TCP 浆料 ，结合液晶显示器(LCD)式光固化 3D 打印技术制备多孔生物支架，采用旋转流变仪 、扫描电子显微镜 、透射电子显微镜 、选区电子衍射花样、傅里叶变换红外光谱仪 、压缩试验等手段对制备的材料和支架进行了表征。并进行流变特性分析、孔隙率计算、断面形貌观察与 X 射线能谱成分分析。系统研究了不同 β-TCP 含量的 PLA/β-TCP 浆料的流变性能与 LCD光固化 3D 打印制备工艺，及对生物支架的表面形态 、微观结构和压缩强度的影响。 结果表明 ，随着 β -TCP 含量的增加，生物支架的孔隙率降低，PLA/β-TCP 浆料中颗粒数量增加，导致低剪切速率下粗糙度和黏度增加；此外，支架纤维表面表现出不同规则的沟槽、粗糙表面特征，压缩强度随着 β -TCP 含量的增加先增加后降低 ，当 β-TCP 质量分数为10% 时，支架压缩强度最高。
Abstract：In order to prepare a PLA/β -TCP bone tissue engineering scaffold with grooving texture, adjustable roughness and high compressive strength, and solve the problem that it is difficult to obtain fiber surface characteristics with controllable texture by traditional piston extrusion 3D printing, photocurable bio-based polylactide, β-tricalcium phosphateas raw material and γ-(2, 3-epoxypropoxy)propyltrimethoxysilane coupling agent as modifier were used. PLA/β-TCP slurry with different β-TCP content was prepared by ball milling and stirring method, and the porous biological scaffold was prepared by Liquid Crystal Display photocuring 3D printing technology. The materials and the scaffold were characterized by rotating rheometer, scanning electron microscope, transmission electron microscope, selected electron diffraction pattern, infrared spectrometer and compression test. Rheological characteristics, porosity calculation, surface profile observation and Energy Dispersive Spectroscopy component analysis were also carried out. The rheological properties of PLA/β-TCP slurry with differentβ-TCP content and the preparation process of LCD photocuring 3D printing were systematically studied, and the effects on the surface morphology, microstructure and compressive strength of biological scaffolds were also studied. The results show that the porosity of the biological scaffold decreases and the number of particles in the PLA/β-TCP slurry increases with the increasing of β-TCP content, resulting in increased roughness and viscosity at low shear rates. In addition, the fiber surface of the scaffold shows different regular grooving and rough surface characteristics, and the compressive strength first increases and then decreases with the increase of β-TCP content, and the strength of the scaffold is the highest when the β-TCP content is 10%.
关键词：聚乳酸/β-磷酸三钙；液晶显示器式光固化；3D打印；生物支架；结构及性能
Keywords：polylactide/β-tricalcium phosphate; photocurable by liquid crystal display; 3D printing; bio-scaffolds; micro‐structure and property
基金：2019 年度广东省普通高校特色创新类项目(2019GKTSCX139)，东莞职业技术学院科研基金项目(2019a12)
本文引用格式：
王波群，揭晓华，雷芳，等.光固化3D打印制备PLA/β-TCP生物支架及性能[J].工程塑料应用，2023，51(8)：32-38.
Wang Boqun，Jie Xiaohua，Lei Fang，et al. Preparation and properties of PLA/β -TCP bio-scaffolds based on photocurable 3D printing[J].Engineering Plastics Application，2023，51(8)：32-38.
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